Protein Domain Mimics as Modulators of Protein–Protein Interactions
نویسندگان
چکیده
منابع مشابه
Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions.
Small molecules which can mimic the key structural facets of protein secondary structure, in particular the α-helix, β-strand, and β-sheet, have been shown to be potent disruptors of protein-protein interactions. Researchers have recently taken the organizational imitation of protein secondary structure to a new level by using intramolecular hydrogen bonds as stabilizing forces in these small m...
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The development of low-molecular-weight agents that modulate protein–protein interactions has been regarded as a difficult goal due to the relatively large and featureless protein interfacial surfaces involved [1–3]. Conventional methods for identifying inhibitors of protein–protein interactions generally involve the preparation and screening of large chemical libraries to discover lead compoun...
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Protein-protein interactions encompass large surface areas, but often a handful of key residues dominate the binding energy landscape. Rationally designed small molecule scaffolds that reproduce the relative positioning and disposition of important binding residues, termed "hotspot residues", have been shown to successfully inhibit specific protein complexes. Although this strategy has led to d...
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The design and generation of molecules capable of mimicking the binding and/or functional sites of proteins represents a promising strategy for the exploration and modulation of protein function through controlled interference with the underlying molecular interactions. Synthetic peptides have proven an excellent type of molecule for the mimicry of protein sites because such peptides can be gen...
متن کاملIdentifying modulators of protein-protein interactions using photonic crystal biosensors.
Inhibitors and activators of protein-protein interactions are valuable as biological probes and medicinal agents but are often difficult to identify. Herein we describe a high-throughput assay, based upon photonic crystal (PC) biosensors, for the identification of modulators of protein-protein interactions. Through the use of a d-biotin-tris-NTA (BTN) hybrid compound, any His6-tagged protein ca...
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ژورنال
عنوان ژورنال: Accounts of Chemical Research
سال: 2017
ISSN: 0001-4842,1520-4898
DOI: 10.1021/acs.accounts.7b00130